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E3 Journal of Medical Research

E3 Journal of Medical Research Vol. 1 (1) pp. 001-005, February 2012; © E3 Journals; ISSN 2276-9900

Cytotoxicity of fevicordin-A from Phaleria macrocarpa (Boerl.) scheff on P388, HeLa, CasKi, TE-2, TE-8 and Prepuce’s Fibroblast cells

Ajeng Diantini , Anas Subarnas , Supriyatna , Jutti Levita * , Rizky Abdulah , Tri Hanggono Achmad , Ahmad Faried , Leri Septiani Faried , Euis Julaeha , Dikdik Kurnia , Savitri Restu Wardhani , Hiroshi Koyama
Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia
*Corresponding Author E-mail:
Accepted 3 January 2012


Cancer is a disease caused by abnormal regulation of cells, particularly the mechanism of cell growth and differentiation. Cancer has high morbidity and mortality. The limitation of medical treatment leads to the findings of an alternative therapy using medicinal plants. Phaleria macrocarpa (Boerl.) Scheff family Thymelaeceae, is a plant which grows in tropical area, mainly in Papua island, Indonesia, and has been used empirically to treat various health problems, amongst which are cancer, diabetes mellitus, and hypertension. Fevicordin A, is a bioactive compound of P. macrocarpa (Boerl.) Scheff. Previous work of Kurnia and his colleagues concluded that this compound has been successfully isolated from the plant and exhibited toxicity on brine shrimp larvas. The objective of this research was to investigate the cytotoxicity of fevicordin A on P388, HeLa, CasKi, TE-2 and TE-8 cancer cells, while its effect on normal cells was performed on fibroblast cells isolated from human prepuce skin. The method used was MTT assay by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reagent. The results of the work indicated that IC50 values of fevicordin-A on the growth of the cancer cells were 0.01 µg/mL (P388), 1.16 µg/mL (HeLa), 12 μg/mL (CasKi), 40 µg/mL (TE-2), and 14.6 µg/mL (TE-8), whereas the IC50 on the growth of fibroblast cells was 24.51 µg/mL. These results suggest that fevicordin A may have potential as a cytotoxic agent against leukemia and cervix cancer.

Keywords: Cytotoxicity; Fevicordin A; Phaleria macrocarpa (Boerl.) Scheff

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