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E3 Journal of Medical Research

E3 Journal of Medical Research Vol. 6 (2) pp. 016-021, April 2017; © E3 Journals; ISSN 2276-9900

Effect of sleep deprivation on hemorheological properties in alloxan induced diabetic rats

Oluranti O.I1 * , Okomafe N.E1 , Fasanmade A.A 1
1 Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
*Corresponding Author E-mail:
Accepted 8 April 2017


Diabetes mellitus with abnormal glucose concentration is associated with changes in hemorheological properties, endothelial function, and platelets hyperactivity. Disturbances may significantly be responsible for diabetes-related vascular complications. People with diabetes are also more likely to have sleep problem/poor sleep. This study therefore investigated the hemorheologic effect of sleep deprivation on alloxan induced diabetic rats. Sixteen healthy male Wistar rats were used for the study randomly divided into non diabetic non sleep deprived, diabetic non sleep deprived, non diabetic sleep deprived and diabetic sleep deprived groups with four animals each. The animals were paradoxically sleep deprived for fourteen days with a sleep deprivation chamber. The result revealed an increase in whole blood viscosity, hematocrit, fibrinogen concentration and relative plasma viscosity in diabetic rats. However, these blood rheological properties decline in sleep deprived diabetic rats. This suggests that diabetes increase hemorheological indices which could lead to vascular complications; while sleep deprivation in normal and diabetic state reduces the hemorheological indices. It is therefore possible that paradoxical sleep deprivation did not synergistically with diabetic condition to alter blood rheological properties but otherwise.

Keywords: Diabetes, paradoxical sleep deprivation, hemorheological properties, vascular complications

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