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E3 Journal of Medical Research

E3 Journal of Medical Research Vol. 5 (2) pp. 021-027, December 2016; © E3 Journals; ISSN 2276-9900

Effects of lead on Epidermal wound Contraction and serum biochemistry in West African dwarf goats

Olaifa Abayomi Kayode 1 * , Adewoye Elsie Olufunke2 , Akpan Matthew Obot3
1 Department of Veterinary Surgery and Reproduction, University of Ibadan, Nigeria
2 Department of Physiology, University of Ibadan, Nigeria
3 Department of Veterinary Anatomy, University of Ibadan, Nigeria.
*Corresponding Author E-mail:
Accepted 16 December 2016


Lead contamination through wound could either be environmental and or systemic sources that impair wound healing in animals. The haematological, biochemical changes including thewound healing effects of topical lead poisoning were therefore investigated using ten adult West African dwarf (WAD) goats, randomly divided into two groups of five animals each. The first group served as the control and the second group was treated with lead chloride solution. Wound contraction was compared between the two groups, haematology and serum biochemistry were analysed at each stage of the healing process. The results revealed a delay in wound contraction in the lead treated group. Erythrocyte sedimentation rate, haemoglobin concentration, packed cell volume, albumin, neutrophil count in the lead treated group decreased significantly (P<0.05).Heart rate and temperature increased significantly (P<0.05, P<0.01) in the treated group. This study concluded that epidermal lead exposure impaired wound healing.

Keywords: Lead, wound contraction, haematology, biochemistry, West African dwarf goats.

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