E3 Journal of Biotechnology and Pharmaceutical Research
E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3 (2) pp. 15 - 21, April 2012; © E3 Journals; ISSN 2141-7474
Solid state fermentation: An effective method for Lovastatin production by fungi over submerged fermentation
Praveen VK , Savitha J *Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi Campus, Bangalore-560056. India.
*Corresponding Author E-mail: drsvtj@yahoo.co.in
Accepted 13 March 2012
Abstract
The Enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG CoA reductase) catalyses conversion of HMG CoA to mevalonate during cholesterol biosynthesis. Lovastatin is used as an anti-cholesterol drug which blocks HMG CoA reductase activity. Lovastatin has been reported to be produced by Submerged Fermentation (SmF) and Solid State Fermentation (SSF) by fungi. Of-late it is used not only as anti-cholesterol drug but as anti-inflammatory agent, cancer cell apoptosis, restoration of renal function, bone disorders treatment; immune-modulatory role is also being investigated. This review provides insight into the different lovastatin production strategies employed by SSF, its advantages over SmF, optimisation parameters, lovastatin genetics etc.
Keywords: HMG CoA. Lovastatin, Fungi, SSF, SmF, Pleiotropic.
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