E3 Journal of Biotechnology and Pharmaceutical Research
E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3 (1) pp. 1-9, March 2012; © E3 Journals; ISSN 2141-7474
Determination of chemical and physical properties of Hyptis pectinata essential oil and their redox active profile
Mairim Russo Serafinia , Daviane Maria Campos Vergnea , Thallita Kelly Rabeloc , Paula dos Passos Menezesa , Ricardo Fagundes da Rochad , Jose Claudio Fonseca Moreirad , Francilene Amaral da Silvaa , Pericles Barreto Alvesb , Hugo Cesar Ramos de Jesusb , Adriano Antunes Souza Araujo*a * , Daniel Pens Gelainda Department of Physiology, Federal University of Sergipe, Brazil.
b Department of Chemistry, Federal University of Sergipe, Brazil.
c Department of Plant Biology, State University of Campinas, Brazil.
d Department of Biochemistry, Federal University of Rio Grande do Sul, Brazil.
*Corresponding Author E-mail: left.ufs@hotmail.com
Accepted 20 December 2011
Abstract
The aim of this study was therefore, to evaluate the redox properties of essential oil from H. pectinata (OEHP). TRAP/TAR assay indicated that OEHP is an antioxidant at 1 mg.mL-1. However, OEHP was not effective in preventing lipoperoxidation in vitro. Furthermore, OEHP reduced deoxyribose oxidative damage by hydroxyl radicals at 1 mg.mL-1, but enhanced hydroxyl production from 1 ng.mL-1 to 10 µg.mL-1. Nitric oxide radical production was inhibited by OEHP at 1 µg.mL-1 to 1mg.mL-1. OEHP did not show any ability to scavenge superoxide radicals and hydrogen peroxide. The results of this study show that OEHP may act as an antioxidant or pro-oxidant depending on its concentration and which species they interact with. Thus, OEHP use for medicinal purposes must be taken with restrictions, and more assays to better determine its safety and biological effects are necessary.
Keywords: H. pectinata, redox profile, sesquiterpenes.
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