E3 Journal of Biotechnology and Pharmaceutical Research
E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3 (8) pp. 132-136, October 2012; © E3 Journals; ISSN 2141-7474
Cortisol and epinephrine effects on galanin secretions in severe fasting
Leili Hosseini1 , H. Khazali2 *1 College of Biological Sciences, Shahid Beheshti university, GC, Tehran, Iran
2 Humanties Dept, Science and Research of Islamic Azad University, Tehran, Iran
*Corresponding Author E-mail: hkhazali@hotmail.com
Accepted 2 July 2012
Abstract
The goal of this study was to determine whether cortisol and epinephrine affects galanin secretions in the sheeps lower levels of their daily requirement. The sheeps were randomly divided into 6 groups. Animals in all groups were fed 100, 50 or 25% of their daily food requirements for 10 days followed by 48 hours of fasting. Consequently, the sheep’s in all groups received infusions of either 1 or 3 ug cortisol/Kg BW, 1 or 3 ug epinephrine /Kg BW and 3 ug cortisol/Kg BW plus 3 ug epinephrine /Kg BW. Blood samples were collected from jugular veins at -30, +30, +90 and +180 minutes of infusions. Fifty and 25 % of daily food intake followed by 48 hours fasting decreased the body weights in the sheeps. Also, twenty five percent of daily food intake followed by 48 hours fasting significantly (P<0.01) increased the mean plasma concentrations of glucose whereas these increases of glucose were not observed in the sheeps fed 100 or 50 % of daily food intake followed by 48 hours fasting. Injection of different dosages of cortisol, epinephrine and combination of cortisol and epinephrine significantly (P<0.01) increased the mean plasma concentrations of glucose in the sheeps of all groups. Injection of different dosages of cortisol did not change the mean plasma concentrations of galanin in the animals of fed all groups. Injection of different dosages of epinephrine and epinephrine plus cortisol significantly (P>0.01) decreased the elevated mean plasma concentration of galanin in the sheep fed 25 and 50% of their daily food intake for 10 days. The results of this experiment indicated that epinephrine may decrease mean plasma concentration of galanin in animal fed lower than their daily food requirement. Injections of cortisol did not change the mean plasma concentrations of galanin in sheep fed restricted.
Keywords: Galanin, cortisol, epinephrine and food restricted.
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