E3 Journal of Biotechnology and Pharmaceutical Research
E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3 (7) pp. 129-131, September 2012; © E3 Journals; ISSN 2141-7474
Anti Salmonella activity of nitric oxide donor and antibiotic: In vitro studies
S.S. HAQUE1 *1 Department of Clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
*Corresponding Author E-mail: sshaq2002@yahoo.co.in
Accepted 19 June 2012
Abstract
Typhoid fever (TF) is an important cause of morbidity and mortality with estimated more than 21 million cases per years. There are number of drugs being used for the treatment of typhoid, but increasing occurrence of multidrug resistant (MDR) strain of Salmonella typhi has complicated its management, that thus it has necessitated the search of formulated drugs for its treatments. Nitric oxide (NO) is a unique molecule produced in a biological system, which regulates a different array of physiological functions and acts as an inter and extra cellular messenger in most mammalian organs. In the present study, antimicrobial tests were done to look for anti-bacterial activity against S. typhi and S.typhimurium. In vitro antimicrobial activity provided the required preliminary observation to select the combination, those have potentially useful properties. As evaluated by the diameter of the inhibition zone, Ciprofloxacin alone, 1/2 L-Arg+1/2 Cip showed potent anti-Salmonella activity 18 mm i.e. 100%.
Keywords: Typhoid, Arginine, Antibiotic, Nitric oxide.
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