E3 Journal of Biotechnology and Pharmaceutical Research
E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3 (6) pp. 104-111, August 2012; © E3 Journals; ISSN 2141-7474
Phytotoxic, cytotoxic and insecticidal activities of Calendula arvensis L.
Rehman Ullah1 * , Muhammad Ibrar1 , Sumaira Shah1 , Ishfaq Hameed11 Department of Botany, University of Peshawar, Pakistan
*Corresponding Author E-mail: rehman_botany@yahoo.com
Accepted 3 July 2012
Abstract
Plants are the natural factories for the synthesis of variety of bioactive compounds. This diverse chemical setup of the plants speaks their important role as biomedicine. These biomolecules are often toxic to both plants and animals. The methanolic extract of Calendula arvensis was screened for its toxic potential against Lemna minor, Artimia salina (Brine shrimps) larvae and some important grains pests. It was observed that C. arvensis exhibited dose dependent toxicity towards Lemna minor, with low toxicity at 10µg/ml and 100µg/ml and moderate activity at 1000µg/ml. Moderate level of cytotoxicity was found LD50 value 9.23µg/ml against brine shrimp larvae. The insecticidal potential was also dose dependent, while different insects showed variable degree of susceptibility to the same treatment. Callosobruchus analis was the most susceptible pest with LD50 0.51mg/ml, where Trogoderma granarium was the most resistive pest among the five tested insect with LD50 90.50mg/ml.
Keywords: Calendula arvensis, Phytotoxicity, Cytotoxicity, Insecticidal
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