Effect of Gentamicin and Amoxicillin on methicillin resistant Staphylococcus aureus (MRSA) against different time and concentrations; Comparative study of the effect of bitter leaf extract and antibiotics (gentamycin and amoxicillin) on bacterial species isolated from wound.

E3 Journal of Biotechnology and Pharmaceutical Research

E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3 (2) pp. 15 - 21, April 2012; © E3 Journals; ISSN 2141-7474

Solid state fermentation: An effective method for Lovastatin production by fungi over submerged fermentation

Praveen VK , Savitha J *
Department of Microbiology and Biotechnology, Bangalore University, Jnana Bharathi Campus, Bangalore-560056. India.
*Corresponding Author E-mail: drsvtj@yahoo.co.in
Accepted 13 March 2012

Abstract

The Enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG CoA reductase) catalyses conversion of HMG CoA to mevalonate during cholesterol biosynthesis. Lovastatin is used as an anti-cholesterol drug which blocks HMG CoA reductase activity. Lovastatin has been reported to be produced by Submerged Fermentation (SmF) and Solid State Fermentation (SSF) by fungi. Of-late it is used not only as anti-cholesterol drug but as anti-inflammatory agent, cancer cell apoptosis, restoration of renal function, bone disorders treatment; immune-modulatory role is also being investigated. This review provides insight into the different lovastatin production strategies employed by SSF, its advantages over SmF, optimisation parameters, lovastatin genetics etc.

Keywords: HMG CoA. Lovastatin, Fungi, SSF, SmF, Pleiotropic.

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